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1

Analyses of a Subset of Patients with Primary Immunodeficiency Diseases (PIDD) Who Switched Modes of Administration of Immunoglobulin (Ig) Therapy during Three Consecutive Studies

Wasserman, Richard L., Gupta, Sudhir, Stein, Mark R., Melamed, Isaac Reuven, Puck, Jennifer M., Engl, Werner, Leibl, Heinz, Rabbat, Christopher J., Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 129 KB

english, 2017

2

Common variable immunodeficiency associated with microdeletion of chromosome 1q42.1-q42.3 and inositol 1,4,5-trisphosphate kinase B (ITPKB) deficiency

Louis, Ankmalika G, Yel, Leman, Cao, Jia N, Agrawal, Sudhanshu, Gupta, Sudhir

Journal:

Clinical & Translational Immunology

Year:

2016

Language:

english

File:

PDF, 1.98 MB

english, 2016

3

Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes

Sudhir Gupta, Sujata Chiplunkar, Choong Kim, Leman Yel, Sastry Gollapudi

Journal:

Mechanisms of Ageing and Development

Year:

2003

Language:

english

File:

PDF, 306 KB

english, 2003

4

Agenda

Haeberle, Adam, Ngo, Leock, Inhaber, Neil, Gelmont, David, Yel, Leman

Journal:

Year:

2002

File:

PDF, 119 KB

2002

5

Efficacy, Safety, Tolerability, and Pharmacokinetics of Human Immune Globulin Subcutaneous, 20% (IGSC 20%): Final Analysis of a Phase 2/3 Study in Patients with Primary Immunodeficiency Disease (PIDD) in North America

Suez, Daniel, Melamed, Isaac, Hussain, Iftikhar, Stein, Mark R., Gupta, Sudhir, Paris, Kenneth, Fritsch, Sandor, Bourgeois, Christelle, Leibl, Heinz, McCoy, Barbara, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 126 KB

english, 2016

6

Safety and tolerability of an intravenously administered alpha1-proteinase inhibitor at an increased infusion rate: a novel, randomized, placebo-masked, infusion rate-controlled, crossover study in healthy adults

Dyck-Jones, Jacqueline, Ngo, Leock Y., Haeberle, Adam, Gelmont, David, Yel, Leman

Journal:

Open Access Journal of Clinical Trials

Year:

2014

File:

PDF, 529 KB

2014

7

An allelic variant of Griscelli disease: presentation with severe hypotonia, mental-motor retardation, and hypopigmentation consistent with Elejalde syndrome (neuroectodermal melanolysosomal disorder)

Ozden Sanal, Leman Yel, Turkan Kucukali, Enid Gilbert-Barnes, Marc Tardieu, Ilhan Tezcan, Fugen Ersoy, Ayse Metin, Genevieve de Saint Basile

Journal:

Journal of Neurology

Year:

2000

Language:

english

File:

PDF, 3.06 MB

english, 2000

8

Infusion Parameters and Adverse Events in Patients With Primary Immunodeficiency Diseases Who Switched to Subcutaneous Human Immune Globulin 20% (Ig20Gly) From Intravenous or Subcutaneous Immune Globulin

Hussain, Iftikhar, Paris, Kenneth, Darter, Amy, Kobrynski, Lisa J., Berner, Todd, McCoy, Barbara, Wang, Ping, Rabbat, Christopher J., Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 125 KB

english, 2018

9

Molecular pathways of thimerosal-induced apoptosis in T cells

Yel, Leman, Makani, Samir, Chiplunkar, Sujata, Gollapudi, Sastry V, Gupta, Sudhir

Journal:

Journal of Allergy and Clinical Immunology

Year:

2002

Language:

english

File:

PDF, 148 KB

english, 2002

10

Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions

Hong Zan, Jinsong Zhang, Ahmed Al-Qahtani, Egest J. Pone, Clayton A. White, Derrik Lee, Leman Yel, Thach Mai, Paolo Casali

Journal:

Molecular Immunology

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

11

Clinical and Immunological Features in IgM Deficiency

Yel, Leman, Ramanuja, Srinivasan, Gupta, Sudhir

Journal:

International Archives of Allergy and Immunology

Year:

2009

Language:

english

File:

PDF, 183 KB

english, 2009

12

Onboarding Experience of Pediatric Patients With Primary Immunodeficiency Diseases With Subcutaneous Human Immune Globulin 20% (Ig20Gly)

Paris, Kenneth, Hussain, Iftikhar, Gupta, Sudhir, Wang, Ping, McCoy, Barbara, Rabbat, Christopher J., Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 156 KB

english, 2018

13

Onboarding Experience of Pediatric Patients With Primary Immunodeficiency Diseases With Subcutaneous Human Immune Globulin 20% (Ig20Gly)

Paris, Kenneth, Hussain, Iftikhar, Gupta, Sudhir, Wang, Ping, McCoy, Barbara, Rabbat, Christopher J., Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

File:

PDF, 156 KB

2018

14

Dyskeratosis congenita: Unusual onset with isolated neutropenia at an early age

LEMAN YEL, ILHAN TEZCAN, ÖZDEN SANAL, FÜGEN ERSOY, A IZZET BERKEL

Journal:

Pediatrics International

Year:

1996

Language:

english

File:

PDF, 373 KB

english, 1996

15

Long-Term Tolerability and Safety Of Facilitated-Subcutaneous Infusion Of Human Immune Globulin G (IgG), 10%, and Recombinant Human Hyaluronidase (rHuPH20) (IGHy): A Phase 3 Extension Study In Patients With Primary Immunodeficiencies (PIs)

Melamed, Isaac Reuven, Wasserman, Richard L., Stein, Mark, Rubinstein, Arye, Puck, Jennifer M., Gupta, Sudhir, Engl, Werner, Leibl, Heinz, Yel, Leman, Schiff, Richard I.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 41 KB

english, 2014

16

Severe T- and B-cell immune deficiency associated with malignant thymoma

Yel, Leman, Liao, Otto, Lin, Fritz, Gupta, Sudhir

Journal:

Annals of Allergy, Asthma & Immunology

Year:

2003

Language:

english

File:

PDF, 1.10 MB

english, 2003

17

Patient experience with subcutaneous immunoglobulin 20%, Ig20Gly, for primary immunodeficiency diseases: a prespecified post hoc analysis of combined data from 2 pivotal trials

Meckley, Lisa M., Wu, Yanyu, Ito, Diane, Berner, Todd, McCoy, Barbara, Yel, Leman

Journal:

Year:

2020

File:

PDF, 2.47 MB

2020

18

A Role of Fas-Associated Death Domain (FADD) in Increased Apoptosis in Aged Humans

Sudhir Gupta, Choong Kim, Leman Yel, Sastry Gollapudi

Journal:

Journal of Clinical Immunology

Year:

2004

Language:

english

File:

PDF, 622 KB

english, 2004

19

A CASE OF INTERLEUKIN-12 RECEPTOR ??-1 DEFICIENCY WITH RECURRENT LEISHMANIASIS

Sanal, Ozden, Turkkani, Gulten, Gumruk, Fatma, Yel, Leman, Secmeer, Gulten, Tezcan, Ilhan, Kara, Ates, Ersoy, Fugen

Journal:

Pediatric Infectious Disease Journal

Year:

2007

Language:

english

File:

PDF, 1.07 MB

english, 2007

20

Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% in Patients With Primary Immunodeficiency Diseases: Interim Analysis of Adverse Events in a Global Post-Authorization Safety Study

Rubinstein, Arye, Bridges, Tracy A., Wedner, H. James, McNeil, Donald, Wasserman, Richard L., Tachdjian, Raffi, Stryk, Steven V., Tarpay, Martha M., Fielhauer, Katharina, Leibl, Heinz, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2019

Language:

english

File:

PDF, 104 KB

english, 2019

21

Homozygous C2 Deficiency: Association with Defective Alternative Pathway Function and Immunoglobulin Deficiency

Sanal, Özden, Yel, Leman, Tezcan, Ilhan, Ersoy, Fügen, Berkel, Izzet

Journal:

International Archives of Allergy and Immunology

Year:

1996

Language:

english

File:

PDF, 649 KB

english, 1996

22

Mutations in the Mu Heavy-Chain Gene in Patients with Agammaglobulinemia

Yel, Leman, Minegishi, Yoshiyuki, Coustan-Smith, Elaine, Buckley, Rebecca H., Trübel, Hubert, Pachman, Lauren M., Kitchingman, Geoffrey R., Campana, Dario, Rohrer, Jurg, Conley, Mary Ellen

Journal:

Boston Medical and Surgical Journal

Year:

1996

Language:

english

File:

PDF, 151 KB

english, 1996

23

Safety and Tolerability of an Intravenously-administered Alpha1-Proteinase Inhibitor (A1PI) at an Increased Infusion Rate: A Randomized, Placebo-Controlled, Phase 4 Study in Healthy Adults

Haeberle, Adam, Ngo, Leock, Inhaber, Niel, Gelmont, David, Yel, Leman

Journal:

Year:

2013

Language:

english

File:

PDF, 190 KB

english, 2013

24

Improving patient tolerability in immunoglobulin treatment: focus on stabilizer effects

Sun, Adam, Teschner, Wolfgang, Yel, Leman

Journal:

Expert Review of Clinical Immunology

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

25

Long-Term Efficacy and Safety of Recombinant Human Hyaluronidase (rHuPH20)- Facilitated Subcutaneous Infusion of Immunoglobulin G (IgG) (HyQvia; IGHy) in Patients with Primary Immunodeficiencies (PI)

Wasserman, Richard L., Stein, Mark R., Melamed, Isaac, Kobrynski, Lisa J., Gupta, Sudhir, Puck, Jennifer M., Rubinstein, Arye, Engl, Werner, McCoy, Barbara, Leibl, Heinz, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2015

Language:

english

File:

PDF, 40 KB

english, 2015

26

Cartilage-Hair Hypoplasia Syndrome: Increased Apoptosis of T Lymphocytes Is Associated with Altered Expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2

Leman Yel, Sudeepta Aggarwal, Sudhir Gupta

Journal:

Journal of Clinical Immunology

Year:

1999

Language:

english

File:

PDF, 1017 KB

english, 1999

27

Local Adverse Reaction Rates Decreased over Time during Treatment with Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Immunoglobulin G (IGHy) in Patients with Primary Immunodeficiency Disorders in the IGHy Phase 3 Studies

Stein, Mark R., Wasserman, Richard L., Melamed, Isaac, Gupta, Sudhir, Kobrynski, Lisa J., Rubinstein, Arye, Rabbat, Christopher J., Engl, Werner, McCoy, Barbara, Leibl, Heinz, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 125 KB

english, 2016

28

Safety and tolerability of subcutaneous immunoglobulin 20% in primary immunodeficiency diseases from two continents

Suez, Daniel, Kriván, Gergely, Jolles, Stephen, Stein, Mark, Gupta, Sudhir, Paris, Kenneth, van Hagen, P Martin, Brodszki, Nicholas, Engl, Werner, Leibl, Heinz, McCoy, Barbara, Yel, Leman

Journal:

Year:

2019

Language:

english

File:

PDF, 862 KB

english, 2019

29

Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

Imai, Kohsuke, Slupphaug, Geir, Lee, Wen-I, Revy, Patrick, Nonoyama, Shigeaki, Catalan, Nadia, Yel, Leman, Forveille, Monique, Kavli, Bodil, Krokan, Hans E

Journal:

Nature Immunology

Year:

2003

Language:

english

File:

PDF, 1.44 MB

english, 2003

30

Selective IgA deficiency with unusual features: Development of common variable immunodeficiency, Sjögren's syndrome, autoimmune hemolytic anemia and immune thrombocytopenic purpura

ÖZDEN SANAL, FÜGEN ERSOY, AYSE METÍN, ÍLHAN TEZCAN, A. ÍZZET BERKEL, LEMAN YEL

Journal:

Pediatrics International

Year:

1995

Language:

english

File:

PDF, 309 KB

english, 1995

31

Tolerability of subcutaneous immunoglobulin 20%, Ig20Gly, in pediatric patients with primary immunodeficiencies

Paris, Kenneth, Haddad, Elie, Borte, Michael, Brodszki, Nicholas, Dérfalvi, Beáta, Maródi, Laszlo, Hussain, Iftikhar, Darter, Amy, Engl, Werner, Leibl, Heinz, McCoy, Barbara, Yel, Leman

Journal:

Year:

2019

File:

PDF, 721 KB

2019

32

Cellular immunodeficiency and autoimmunity in long-term mineral oil administration

Yel, Leman, Chen, William, Gupta, Sudhir

Journal:

Annals of Allergy, Asthma & Immunology

Year:

2004

Language:

english

File:

PDF, 869 KB

english, 2004

33

T-ALL with monoclonal gammopathy and hairy cell features

Sevgi Yetgin, Lale Olcay, Leman Yel, Murat Tuncer, İlhan Tezcan, Esra Erdemli, Ahmet Faik Öner, Frederick G. Behm

Journal:

American Journal of Hematology

Year:

2000

Language:

english

File:

PDF, 292 KB

english, 2000

34

Severe combined immunodeficiency associated with malignant thymoma

Liao, Otto, Yel, Leman, Gupta, Sudhir

Journal:

Journal of Allergy and Clinical Immunology

Year:

2002

Language:

english

File:

PDF, 264 KB

english, 2002

35

Autoimmunity and Inflammation in X-linked Agammaglobulinemia

Hernandez-Trujillo, Vivian P., Scalchunes, Chris, Cunningham-Rundles, Charlotte, Ochs, Hans D., Bonilla, Francisco A., Paris, Ken, Yel, Leman, Sullivan, Kathleen E.

Journal:

Journal of Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 154 KB

english, 2014

36

Review of the Onboarding Experience of a New 20% Human Immune Globulin for Subcutaneous Administration (SCIG 20%): Correlation of Infusion Parameters and Adverse Events (AEs)

Gupta, Sudhir, Stein, Mark R., Melamed, Isaac Reuven, Hussain, Iftikhar, Paris, Kenneth, Engl, Werner, McCoy, Barbara, Rabbat, Christopher J., Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 126 KB

english, 2017

37

Characterization of naı̈ve, memory and effector CD8+ T cells: effect of age

Sudhir Gupta, Ruifen Bi, Kevin Su, Leman Yel, Sujata Chiplunkar, Sastry Gollapudi

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 293 KB

english, 2004

38

A New Subcutaneous Immunoglobulin 20% Formulation (SCIG 20%) with Individualized Infusion Parameters Resulted in a Positive Safety and Tolerability Profile in Patients with PIDD in Europe and North America

Suez, Daniel, Krivan, Gregely, Jolles, Stephen R., Hussain, Iftikhar, Stein, Mark R., Gupta, Sudhir, Paris, Kenneth, van Hagen, Martin, Brodszki, Nicholas, McCoy, Barbara, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 127 KB

english, 2017

39

Tolerability of Ig20Gly During Onboarding in Patients With Primary Immunodeficiency Diseases

Gupta, Sudhir, Stein, Mark, Hussain, Iftikhar, Paris, Kenneth, Engl, Werner, McCoy, Barbara, Rabbat, Christopher J., Yel, Leman

Journal:

Annals of Allergy, Asthma & Immunology

Year:

2019

Language:

english

File:

PDF, 596 KB

english, 2019

40

Antibody Response to a Seven-Valent Pneumococcal Conjugated Vaccine in Patients with Ataxia-Telangiectasia

Ozden Sanal, Fugen Ersoy, Ilhan Tezcan, Ayse Metin, Tuba Turul, Semra Gariboglu, Leman Yel

Journal:

Journal of Clinical Immunology

Year:

2004

Language:

english

File:

PDF, 786 KB

english, 2004

41

PARVOVIRUS B19-INDUCED PERSISTENT PURE RED CELL APLASIA IN A CHILD WITH T-CELL IMMUNODEFICIENCY

Tavil, Betul, Sanal, Özden, Turul, Tuba, Yel, Leman, Gurgey, Aytemiz, Gumruk, Fatma

Journal:

Pediatric Hematology-Oncology

Year:

2009

Language:

english

File:

PDF, 98 KB

english, 2009

42

Selective IgA Deficiency

Journal:

Journal of Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 163 KB

english, 2010

43

Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Immunoglobulin G (IgG) (IGHy) in Patients with Primary Immunodeficiency Disease (PIDD): Infections over Time

Wasserman, Richard L., Stein, Mark R., Kobrynski, Lisa J., Gupta, Sudhir, Grant, J. Andrew, Rubinstein, Arye, Rabbat, Christopher J., Engl, Werner, McCoy, Barbara, Leibl, Heinz, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 158 KB

english, 2016

44

Analysis of Safety and Tolerability Data in Pediatric Patients with Primary Immunodeficiency Diseases from Two Phase 2/3 Studies of Human Immune Globulin Subcutaneous, 20%

Paris, Kenneth, Haddad, Elie, Hussain, Iftikhar, Brodszki, Nicholas, Darter, Amy Liebl, Engl, Werner, McCoy, Barbara, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 123 KB

english, 2017

45

Onboarding Experience of Patients With Primary Immunodeficiency Diseases Who Switched to Subcutaneous Human Immune Globulin 20% (Ig20Gly) From Intravenous or Subcutaneous Immune Globulin 10%

Gupta, Sudhir, Hussain, Iftikhar, Paris, Kenneth, Stein, Mark, McCoy, Barbara, Wang, Ping, Rabbat, Christopher J., Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 127 KB

english, 2018

46

A Case of Leukocyte Adhesion Deficiency (LAD) Presenting with Nasal Septum Perforation and Necrotizing Ulcer on Ala Nasi

Tezcan, Ilhan, Yel, Leman, Önerci, Metin, Sanal, Özden, Ersoy, Fügen, Berkel, A. Izzet

Journal:

American Journal of Rhinology

Year:

1996

Language:

english

File:

PDF, 1.99 MB

english, 1996

47

Health-Related Quality of Life and Treatment Satisfaction in North American Patients with Primary Immunedeficiency Diseases Receiving Subcutaneous IgG Self-Infusions at Home

Uwe Nicolay, Peter Kiessling, Melvin Berger, Sudhir Gupta, Leman Yel, Chaim M. Roifman, Ann Gardulf, Florian Eichmann, Stefan Haag, Cordula Massion, Hans D. Ochs

Journal:

Journal of Clinical Immunology

Year:

2006

Language:

english

File:

PDF, 238 KB

english, 2006

48

Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria

Yel, Leman, Brown, Lorrel, Su, Kevin, Gollapudi, Sastry, Gupta, Sudhir

Journal:

International Journal of Molecular Medicine

Year:

2005

Language:

english

File:

PDF, 2.07 MB

english, 2005

49

Griscelli Disease: Genotype–Phenotype Correlation in an Array of Clinical Heterogeneity

Ozden Sanal, Fúgen Ersoy, Ilhan Tezcan, Ayşe Metin, Leman Yel, Gaël Ménasché, Aytemiz Gürgey, Izzet Berkel, Geneviève de Saint Basile

Journal:

Journal of Clinical Immunology

Year:

2002

Language:

english

File:

PDF, 40 KB

english, 2002

50

Improved Treatment Satisfaction with a New Human Subcutaneous Immunoglobulin (SCIG 20%) in Patients Previously Treated with IVIG

Meckley, Lisa, Ito, Diane, Hu, Xingdi, Berner, Todd, Yel, Leman

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 122 KB

english, 2017

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